Midway by means of his vocation, Cees Dekker reinvented himself. Soon after years of hardcore physics, he shifted his emphasis to ‘nanobiology’ at the switch of the millennium. A phrase he coined himself, to be a issue of point.
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Non-equilibrium folding of unique DNA molecules recaptured approximately 1000 situations in the strong point out nanopore
2010, made a brand new way (‘wedging transfer’) to manipulate nanostructures; very first report of DNA translocation by graphene nanopores; and understood hybrid nanopores by directed insertion of α-hemolysin into good-state nanopores
Cornelis (Cees) Dekker (Haren, 7 april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en met 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
We use nanofabricated microfluidic constructions to pattern spatial boundaries for germs and biomimetic vesicles with reconstituted protein networks and this evaluate the elemental purpose of spatial confinement within the molecular and mobile stage. Our assignments contain the following:
Dynamic ParB–DNA interactions initiate and sustain a partition condensate for bacterial chromosome segregation
In 1993, for a young and eager associate professor at Delft College of Technological know-how, I had at first centered the investigate efforts of my group on measuring the electrical conductance of only one conducting-polymer molecule. Within two a long time, we experienced made a tool by which an individual wire of the phthalocyaninepolysiloxane polymer was linked concerning two closely spaced metal nanoelectrodes.
There was 1 problem though — we didn't notice any measurable electrical conduction from The only polymer molecules. We concluded that at the single-molecule level, conducting polymers were being essentially not these wonderful conductors, which was fairly disappointing. We Therefore broadened our see to test to search out far more promising molecules.
‘The concept that You can find this kind of detail as a commencing, a major bang, is already a fascinating signpost to consider that there was a creator. But more generally, and on the basis of pure rationality, I also get there in a Christian interpretation of fact. An atheistic worldview can be a naturalistic worldview: basically, you'll find only atoms and organic forces that we are able to measure.
‘That fears the synthetic cell, as Portion of the Dutch BaSyC initiative. Craig Venter seemed major-down in those days and recognized about 5 hundred genes that happen to be minimally required for the performing mobile. We want to glance base-up: how can we move from a few molecules to an entire Organic program?
Visualization of unstained DNA nanostructures with Innovative in-target transmission electron microscopy methods
Stable-point out nanopores have tested to generally be a shockingly versatile probe for one-molecule Assessment of DNA. I'll explain a number of our modern results – especially DNA knots – along with our attempts to broaden the capabilities of good-point out nanopores even even further, while in the route of single-protein detection, graphene nanopores, plasmonic nanopores, ceesdekker.net and DNA origami nanopores.